Heart failure risk tied to kidneys

Heart failure risk tied to kidneys
Key Renal DNA Sequence Variant Plays Significant Role: Experts

Washington: For the first time, an international team of scientists has discovered a key kidney DNA sequence variant which plays a significant role in increasing the riskof heartfailure.
The DNA variant, a change in a single letter of the DNA sequence which is common in people, impairs channels that control kidney function, the researchers found. “It’s not a heart gene,” said Gerald Dorn, from the Washington University School of Medicine in St Louis, whoisthelead author of thestudy.
“It’s a kidney gene. This protein is not even expressed in the heart. Nobody has previously considered that kidney-specific gene defects might predispose you to heart failure.”
Heart failure is diagnosed when theheartcan nolonger provide sufficient blood to the body. It can have a number of causes, including high blood pressure, cancer therapy, viral infections of the heart or heart attack.
But the unexpected findings, publishedin thejournalTheProceedings of the National Academy of Sciences, highlighted the advantage of performing genome-wide studies to find DNA sequence variants associated with disease.
“I was surprised by the finding,” says Thomas Cappola, of the University of Pennsylvania Schoolof Medicine,whowas also a lead investigator on the study.
“This is a good example of how taking unbiased approaches to study human disease can lead you to unexpected targets.” PTI

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